From a research question to a publication-ready review with PRISMA flow, Risk of Bias, and journal recommendations — in minutes, not days.
Start with a research question (the AI will translate it into an optimized PubMed query) or enter terms manually. Specialty quick-starts let you pre-load the right MeSH context, and the Advanced panel adds date period and study-type filters (RCT, systematic review, in vitro, preprints…).
After fetching metadata, EvidenceScope extracts MeSH terms and title keywords from your results, ranked by frequency. Drag terms into ALL of these, ANY of these, or NONE of these zones to refine the set with boolean logic — without rewriting your PubMed query.
Slide to keep only journals above a chosen impact threshold. Powered by OpenAlex (2-year mean citedness, 250K+ journals — live API) with SCImago SJR as fallback. Add a citation-count cutoff (NIH iCite) to prioritize papers that have already been validated.
Each result shows title, authors, journal, impact factor, quartile, year, PMID, and an expandable abstract. Click Include or Exclude to screen each article — or use Include all to bulk-screen. Open-access articles in PubMed Central get a Figures & tables button for AI extraction.
One click extracts structured data per article: Population, Intervention, Comparison, Outcome (PICO), plus study design, sample size, country, and a one-line bottom-line takeaway. Powered by Claude — no manual data extraction.
Cochrane-style 7-domain Risk of Bias assessment per article (D1-D7), with traffic-light visualization. Get an overall judgment per study and a Risk of Bias Overview diagram for all included studies — ready to drop into your manuscript.
Generate an up to 8 000-word narrative review from your included articles. Includes a cited introduction drawing from the references of your source papers, a thematic body citing every paper, future perspectives, conclusion, PRISMA 2020 checklist, PMID list, PRISMA flow diagram, and RoB overview. Downloadable as Word.
Sepsis remains the leading cause of mortality in intensive care units worldwide, with an estimated 49 million cases annually {Singer2016}. Despite advances in supportive care, mortality remains stubbornly high at 25-30% for severe sepsis {Rhodes2017}. The pathophysiology of sepsis-induced organ failure is incompletely understood, but converging evidence implicates mitochondrial dysfunction as a central mechanism {Brealey2002, Singer2014}. Mitochondria are the principal cellular sites of ATP generation and play key roles in apoptosis regulation and innate immunity. During sepsis, mitochondrial respiration is impaired through multiple mechanisms — including decreased substrate availability, electron transport chain inhibition, and increased reactive oxygen species (ROS) production {Cherry2017}…
Recent work has converged on three core findings. First, peripheral blood mononuclear cell (PBMC) respiration is severely impaired in septic patients {Smith2024, Chen2024}. Smith et al. demonstrated in a multi-center RCT (n=248) that the mitochondria-targeted antioxidant MitoQ improved 28-day survival from 56% to 71% (HR 0.62, 95% CI 0.43-0.89), with no excess adverse events {Smith2024}. Second, mitochondrial membrane potential collapse precedes clinical organ failure by 24-48 hours {Rodriguez2023}. Third, mitochondrial DNA released into circulation acts as a damage-associated molecular pattern (DAMP) and drives inflammasome activation {Wei2024}…
Three therapeutic approaches have shown promise. Mitochondria-targeted antioxidants (MitoQ, MitoTEMPO) reduce ROS production at the source, with the strongest evidence from Smith et al. {Smith2024}. Metabolic resuscitation with thiamine, ascorbate, and corticosteroids…
Every citation is a real PMID from your filtered set — no hallucinated references. The full output also includes Methods, Discussion, Limitations, PRISMA 2020 checklist (16 items), and a downloadable Word file.
Auto-generated PRISMA 2020 flow diagram showing search-to-inclusion numbers — directly downloadable as SVG and embedded in the AI Review Word file. No more drawing it manually in PowerPoint.
Export the full dataset to Excel with every column: title, authors, journal, year, PMID, IF, quartile, citations, screening status, PICO, study design, sample size, country, all 7 RoB domains, abstract. The AI Review downloads as a formatted Word document with embedded PRISMA flow and RoB overview.
| PMID | Title | Journal | IF | Design | Population | RoB |
|---|---|---|---|---|---|---|
| 38456123 | Mitochondrial dysfunction in sepsis… | Nature Medicine | 58.7 | RCT | ICU adults n=248 | Low |
| 38221045 | Mitochondria-targeted therapies… | Critical Care Medicine | 8.8 | Review | N/A | Moderate |
| 37892341 | Reactive oxygen species… | Intensive Care Medicine | 41.3 | Cohort | Septic shock n=142 | Serious |
A separate workflow: paste your manuscript title + abstract and EvidenceScope finds the most relevant journals by analyzing where similar published papers appear. Each journal is enriched with CiteScore, H-index, OA status, APC cost, and the Dutch University deal (free APC for VSNU institutions: RUG, EUR, RU, UL, UM, UU, UvA, VU, WUR).
| # | Journal | Publisher | CiteScore | H-idx | OA | NL deal | Hits |
|---|---|---|---|---|---|---|---|
| 1 | Critical Care Medicine Critical Care Medicine, Emergency Medicine | Wolters Kluwer | 8.8 | 253 | Hybrid | Free | 14 |
| 2 | Intensive Care Medicine Critical Care Medicine, Anesthesiology | Springer | 41.3 | 221 | Hybrid | Free | 9 |
| 3 | Shock Critical Care, Surgery, Hematology | Wolters Kluwer | 5.8 | 156 | Hybrid | Free | 8 |
| 4 | Mitochondrion Cell Biology, Biochemistry | Elsevier | 7.4 | 132 | Hybrid | 15% discount | 7 |
| 5 | Free Radical Biology and Medicine Biochemistry, Cell Biology | Elsevier | 10.6 | 230 | Hybrid | 15% discount | 6 |
| 6 | Frontiers in Immunology Immunology, Microbiology | Frontiers | 11.0 | 191 | OA | Free | 5 |
Free tier: 3 AI Reviews, 5 enrichments, 5 Risk of Bias assessments — enough to fully test the platform on a real project.